He doesnt NEED a head unit. But it will sound much better with one. You can tap into the stock radios signal through the rear speakers. Feed there signal into the high level inputs of the amp (if available), if amp has no high level inputs, use a line level converter.
as for everything else, it's standard wiring, inline fuse, and all that other crap. For wire size and fuse size post what size amp he has. Well, make and model would be best. If not me, someone will get back to you with an answer!