First start by a basic tune-up: Spark-plugs, air filter, fuel filter and if needed spark plug wires.
How old is your oil? maybe an oil change can help, if the old one is all sludgy and old.
Check your PCV (positive crank ventilation) valve, its like 4$ in a parts store, and does a huge difference when its cloged. Its very easy to change too.
Do you have any exhaust leaks? An exhaust leak makes u loose ur backpressure and this, depending on the car and place of the leak, can let some good fuel our of the exhaust valve during the exhaust/intake of the piston, when the two valves are open at the same time. Also check for an obstructed exhaust, it can cause fuel consumption too because it creates too much backpressure,
Check your engine for codes, see if any sensors are misreading. Some sensors can make a huge difference, again depending on the car, the year and so on. O2 sensors usually make a huge difference, because the make the car run too rich, so you burn more fuel and the car has less performance.