Un autre preuve qui explique pourquoi les strains 1:1 sont les plus efficaces côté medical.
Another recent study, showing the synergistic effect of THC+CBD in a mouse model of multiple sclerosis (MS).
Researchers from the University of South Carolina School of Medicine demonstrated that when mice with experimental autoimmune encephalomyelitis were given THC+CBD (10 mg/kg each), it reduced neuroinflammation, suppressed immune cells (Th17 and Th1), decrease in the levels of brain infiltrating CD4+ T cells and pro-inflammatory molecules (IL-17, INF-γ, TNF-α, IL-1β, IL-6, and TBX21), while increasing anti-inflammatory phenotype (FoxP3, STAT5b, IL-4, IL-10, and TGF-β).
These effects were not achieved when giving the same doses of THC or CBD separately and were mediated by activation of CB1 and CB2 receptors.
This important effect of phytocannabinoids along with other previously demonstrated effects (antispastic, analgesia, antioxidant, neuroregenerative) make cannabinoid preparations so effective in the treatment of MS and other medical conditions.
Zinah Zamil Al-Ghezi, Kathryn Miranda, Mitzi Nagarkatti and Prakash S. Nagarkatti. Combination of Cannabinoids, Δ9- Tetrahydrocannabinol and Cannabidiol, Ameliorates Experimental Multiple Sclerosis by Suppressing Neuroinflammation Through Regulation of miRNA-Mediated Signaling Pathways. Front. Immunol., 21 August 2019 |
https://doi.org/10.3389/fimmu.2019.01921