I hate the fact that wanting to drive a manual transmission car today is nearly impossible. I don't care how advanced or better or quicker the automatics are just give me my stick shift.
The only other thing I dislike is that you no longer have road feeling through the steering wheel, that's been totally eliminated now. You're just turning a soft steering wheel that doesn't give you any feedback.
Finally I don't like all the additional stuff that are being made as selling features. I won't buy a car because it has on star, my link, wireless capabilities, that it can call my mom, that the wipers turn on by themselves or that it can park itself. I know that stuff will work on the kids and the old ladies that hate to parallel park but I hate it when they use that as a selling argument for me. If I wanted a car that could park itself or drive without me I'd take a taxi or a bus.
On the flip side they've gotten safer, quieter on the inside, more comfortable for the most part and reliability is mostly good. Lot's of interesting stuff happening now with turbos and direct injection. Diesels are better then ever too.